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Item Classification List

  1. Basic Science
    1. Immune mechanisms
      1. Antigens including superantigens, determinants
      2. Antigen presentation & histocompatibility
      3. Immunoregulation / Tolerance
      4. Immunogenetics / Molecular Biology
      5. Immunoglobulins (including IgE)
      6. T & B Cell Ligand-Receptor Interactions & Signal Transduction / Cell Activation / Anergy
      7. Cytokines / Chemokines & Their Receptors
      8. Adhesion Molecules
      9. Complement, coagulation, fibrinolytic & kallikrein–kinin immune system
      10. Immediate Hypersensitivity (IgE-Mediated)
      11. IgG/IgA/IgM/FcR-Mediated Reactions (e.g. ADCC, immune complex, opsonization)
      12. Delayed type hypersensitivity / Cell-mediated immunity
      13. Innate Immunity
    2. Cells Involved in Immune Responses (Differentiation, Origin, Reception, Interactions, Secretions)
      1. Lymphocytes
        1. T cells & receptors
        2. B cells & receptors
        3. Other lymphocytes (e.g. NK, NK-T)
      2. Antigen-Presenting Cells (e.g., Monocytes, Macrophages, Dendritic Cells)
      3. Mast Cells / Basophils
      4. Eosinophils
      5. Neutrophils
      6. Other cells (e.g. endothelial, epithelial, smooth muscle, fibroblasts, platelets)
    3. Anatomy / Physiology / Pathology
      1. Lymphoid system immune & privileged organs
      2. Upper Airway, Nose, Sinuses, Middle Ear
      3. Lower Airway
      4. Skin
      5. Gastrointestinal
    4. Research Principles
      1. Experimental Design
      2. Data Analysis & Biostatistics
      3. Epidemiology
      4. Human subject protection & adverse event reporting

  2. Clinical Science
    1. Hypersensitivity Disorders (epidemiology, risk factors, pathogenesis, clinical presentation, diagnosis & differential diagnosis, treatment/management)
      1. Nasal/sinus (e.g. allergic rhinitis, allergic fungal sinusitis)
      2. Ocular
      3. Eczema / Atopic Dermatitis
      4. Asthma
      5. Adverse Reactions to Foods
      6. Anaphylaxis (including Idiopathic, Exercise, Latex)
      7. Adverse Reactions to Stinging Insects
      8. Urticaria
      9. Occupational Diseases, hypersensitivity pneumonitis & ABPA
      10. COPD & Interstitial lung disease
      11. Contact Hypersensitivity
    2. Immunological Disorders (epidemiology, risk factors, pathogenesis, clinical presentation, diagnosis & differential diagnosis, treatment/management)
      1. Hereditary & Acquired Angioedema
      2. Congenital (Primary) Immunodeficiencies
        1. Complement
        2. Phagocyte
        3. T Cell
        4. B Cell / Antibody Deficiencies
        5. Combined /Other
      3. Acquired (Secondary) Immunodeficiencies
      4. Eosinophilic gastrointestinal disorders
      5. Hypereosinophilic Syndromes
      6. Mastocytosis / Mast Cell Disorders
      7. Infectious Diseases (e.g. microbiology & pathogenesis- Tick-borne, TB, leprosy, hepatitis, syphilis, otitis, sinusitis, pneumonia, bronchiolitis, croup)
      8. Clinical presentation & diagnostic approach to other immune disorders/conditions (e.g. autoimmune/rheumatologic diseases, immunohematologic malignancies & disorders, autoinflammatory diseases, cryopathic disorders, granulomatous disease, transplantation, cystic fibrosis, reproductive & neonatal immunology)
    3. Non-Disease Specific Pharmacology / Therapeutics
      1. Allergen Avoidance
      2. Immunotherapy
      3. Antihistamines
      4. Complementary & Alternative Medicine
      5. Beta-Agonists & Antagonists
      6. Leukotriene Pathway Modulators
      7. Mast Cell Stabilizers
      8. Anticholinergics & methylxanthines
      9. Glucocorticoids
      10. Immunomodulator/adjuvant/gene therapy (e.g. DNA, CpG ODNs, cytokines, monoclonal antibodies)
      11. Immune globulin therapy (e.g. replacement, immunomodulation, IVIG, SCIG, hyperimmune, non-monoclonal)
      12. Aspirin & Non-Steroidal Anti-Inflammatory Agents
      13. Cardiopulmonary Resuscitation
      14. Vaccines (e.g. indications, immune response, adjuvants, efficacy, reactions)
      15. Dermatologic & Ophthalmic Treatments
      16. Controversial Treatments
      17. Surgical Intervention with Sinuses / Middle Ear
      18. Adverse Reactions to Drug & Biologicals- epidemiology, mechanism & management principles
    4. Specific Diagnostic Modalities
      1. Skin testing (e.g. prick, delayed type hypersensitivity, patch)
      2. Nasal, conjunctival & bronchial provocation
      3. Pulmonary function testing (e.g. spirometry, bronchoprovocation, body plethysmography, ENO, IOS)
      4. Mucociliary function & nasal/lung (e.g. secretions, lavage or biopsy)
      5. Laboratory Testing
        1. Ig measurement (e.g. total, specific, immune complexes)
        2. Mediator Measurement (e.g. secreted, intracellular, signaling)
        3. Leukocyte phenotyping (e.g. flow cytometry, spectratyping, memory & activation markers)
        4. Cellular Function (e.g. Proliferation, Cytotoxicity, Chemotaxis, Phagocytosis, Killing)
        5. Complement, coagulation, fibrinolytic & kallikrein–kinin immune system evaluation
        6. Molecular Biology Techniques (e.g. TRECs. PCR, in situ hybridization, cell purification, gene chip, hybridoma, Ig/TCR gene rearrangement)
        7. Laboratory quality control & oversight
      6. Imaging
      7. Oral Challenge (e.g. food, drug)
      8. Controversial Tests / Misuse of Standard Tests
    5. Allergens / Antigens (non-disease specific properties, measurement & avoidance)
      1. Aerobiology (e.g. pollens & measurement)
      2. Molds & Fungi
      3. Indoor Allergens
      4. Animal, insect & arthropod allergens
      5. Pollutants
      6. Allergen extract standardization & stability

Updated: April 2015



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