American Board of Allergy and Immunology

Item Classification List 2006

  1. Basic Science
    1. Immune mechanisms
      1. Antigens / Antigen Presentation/Super Antigens
      2. Major Histocompatibility Complex
      3. Immunoregulation / Tolerance
      4. Immunogenetics / Molecular Biology
      5. Immunoglobulins (including IgE)
      6. T and B Cell Ligand-Receptor Interactions and Signal Transduction / Cell Activation / Anergy
      7. Cytokines / Interleukins / Chemokines and Their Receptors
      8. Role of Adhesion Glycoproteins in Inflammation
      9. Complement / Kinins
      10. Mucosal Immunity
      11. Transplantation / Tumor immunology
      12. Innate Immunity/TLRs
    2. Cells Involved in Immune Responses (Differentiation, Origin, Reception, Interactions, Secretions)
      1. Lymphocytes
        1. T cells
        2. B cells (Ig Production, Cytokine Regulation)
        3. NK cells
        4. LAK cells
      2. Monocytes / Macrophages / Dendritic Cells (i.e., Antigen-Presenting Cells)
      3. Mast Cells / Basophils
      4. Eosinophils
      5. Neutrophils
      6. Platelets
      7. Endothelial / Epithelial / Smooth Muscle / Fibroblasts
    3. Specific Immune Responses
      1. Immediate Hypersensitivity (IgE-Mediated)
        1. IgE Receptor / Allergen Binding
        2. Biochemical Events
        3. Preformed Mediator Release
        4. Formation of Mediators / Arachidonic Acid Metabolism
        5. Modulation of Mediator Release
        6. Cytokines
        7. Effect of Mediators on Target Organs
        8. Role of Eosinophils & Neutrophils
        9. Early - vs Late-Phase Reactions
      2. IgG/IgA/IgM-Mediated Reactions
        1. Opsonization
        2. Complement Fixation & Fcg Receptor Activation
        3. Antibody-Dependent Cell-Mediated Cytotoxicity
        4. Antibody-Mediated Immune Regulation
      3. Immune Complex- Mediated
      4. Cell-mediated
        1. CD4+ Cells (TH1, TH2) and T regulatory cells
        2. CD8+ Cells
        3. NK / LAK Cells
        4. NKT cells
    4. Laboratory Tests
      1. Ig Measurement / Total & Specific
      2. Mediator Measurement
      3. Cell Surface Markers and Receptors (Flow Cytometry)
      4. Lymphocyte Function: Proliferation, Cytotoxicity
      5. Chemotaxis
      6. Phagocytosis / Killing
      7. Hybridoma / Monoclonal Antibodies
      8. Immune Complexes
      9. Complement
      10. Molecular Biology Technology including TRECs. RTPCR, in situ hybridization, cell purification, gene chips
      11. Intracellular Signaling/Mediator Detection
    5. Anatomy / Physiology / Pathology
      1. Lymphoid System & Organs
      2. Upper Airway, Nose, Sinuses, Middle Ear
      3. Lower Airway (Remodeling)
      4. Skin
      5. Renal
      6. Gastrointestinal
    6. Research Principles
      1. Experimental Design
      2. Data Analysis and Biostatistics
      3. Epidemiology
      4. Informal Consent
      5. Adverse Event Reporting
  2. Clinical Science
    1. Hypersensitivity Disorders
      1. Rhinitis
      2. Sinusitis
      3. Otitis
      4. Conjunctivitis
      5. Eczema, Atopic Dermatitis
      6. Asthma
        1. Children
        2. Adults
      7. Occupational Diseases
      8. Aspergillosis
      9. Hypersensitivity Pneumonitis
      10. Interstitial Pneumonitis
      11. COPD / Bronchitis / RSV/ Croup
      12. Food Allergy
      13. Anaphylaxis (including Idiopathic, Exercise, Latex)
      14. Stinging Insect Allergy
      15. Drug Reactions
      16. Urticaria
      17. Contact Hypersensitivity
      18. Vaccine (Principles and Reactions)
    2. Immunological Disorders
      1. Hereditary and Acquired Angioedema
      2. Complement Deficiencies
      3. Congenital (Primary) Immunodeficiencies
      4. Acquired (Secondary) Immunodeficiencies
        1. HIV/AIDS-related
        2. Non-HIV/AIDs-related
      5. Neutrophil Adhesion Glycoprotein Defects
      6. Systemic Autoimmune Disease (RA, SLE, Other Vasculitis)
      7. Immunologic Rejection / Organ Transplantation
      8. Graft vs. Host Reaction / Bone Marrow Transplantation
      9. Immune Endocrinopathies (Thyroid, Diabetes, Adrenal)
      10. Immunologic Renal Diseases
      11. Immunologic Skin Diseases
      12. Immunologic Eye Diseases
      13. Inflammatory Gastrointestinal Diseases
      14. Immunologic Neuropathies
      15. Hypereosinophilic Syndromes
      16. Leukemias, Lymphomas, Myelomas
      17. Sarcoidosis
      18. Cryopathies (Amyloidosis)
      19. Mastocytosis
      20. Immunohematologic Diseases
      21. Cystic Fibrosis
      22. Reproductive Immunology
      23. Immunologic Aspects of Infectious Diseases (ie. Lyme Disease, TB, Leprosy, Hepatitis, Syphilis)
    3. Pharmacology / Therapeutics
      1. Allergen Avoidance (Benefits / Risks)
      2. Immunotherapy
      3. Histamine Antagonists
      4. Theophylline
      5. Beta-Agonists and Antagonists
      6. Calcium / Sodium Channel Blockers Leukotriene Pathway Modulators
      7. Mast Cell Stabilizers (Cromolyn / Nedocromil)
      8. Anticholinergics
      9. Glucocorticoids
      10. Immunomodulators / Suppressives (including anti-IgE, DNA,CpG ODNs)
      11. Immunoglobulin Replacement Therapy
      12. Cytokine and Cytokine Receptor-Mediated Therapy (IFN, GM-CSF, IL-2)
      13. Cellular Immune Reconstitution
      14. Immunoprophylaxis Vaccine
      15. Apheresis
      16. Anti-inflammatory Agents (including COX-1 & 2)
      17. Surgical Intervention with Sinuses / Middle Ear
      18. Controversial Treatments
      19. Cardiopulmonary Resuscitation
      20. Dermatologic and Ophthalmic Treatments
      21. Gene Transfer
    4. Specific Diagnostic Modalities
      1. Skin tests (Immunoassay for Specific IgE, PRIST)
      2. Nasal Provocation
      3. Pulmonary Function Tests
      4. Bronchial Provocation
      5. Nasal and Sputum Smears
      6. Mucociliary Function
      7. Serologic Tests
        1. ELISA
        2. Western Blot
      8. Serologic Tests for Autoimmunity
      9. Molecular Diagnostics / Tissue Typing
      10. Imaging
      11. Flow Cytometry / Cell Surface Markers
      12. Controversial Tests / Misuse of Standard Tests
      13. Delayed Type Hypersensitivity Tests
      14. Food Challenge
    5. Allergens / Antigens
      1. Pollens
      2. Molds and Fungi
      3. Indoor Allergens
      4. Animal Proteins
      5. Pollutants
      6. Standardization of Antigens
      7. Stability of Antigens
      8. Environmental Controls
      9. Aerobiology
      10. Autoantigens
      11. Infectious Agents
      12. Foods
      13. Venoms

    Updated: 9/27/06



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